Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues
نویسندگان
چکیده
منابع مشابه
COELIAC DISEASE Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues
Background: Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. Aims: To evaluate whether antigens other than TG2 contribute to EMA/ARA/JEA reactions. Patients:...
متن کاملMissing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues.
BACKGROUND Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. AIMS To evaluate whether antigens other than TG2 contribute to EMA/ARA/JEA reactions. PATIENT...
متن کاملIn vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies.
BACKGROUND IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may thereby contribute to disease manifestations. AIMS To investigate intestina...
متن کاملSMALL INTESTINE In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies
Background: IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may thereby contribute to disease manifestations. Aims: To investigate intestina...
متن کاملPositive tissue transglutaminase antibodies with negative endomysial antibodies: low rate of celiac disease.
BACKGROUND Screening for celiac disease is based on the sequential evaluation of serologic tests and intestinal biopsy; an optimal screening protocol is still under investigation. The screening policy of one of the main healthcare providers in Israel (Maccabi) consists of measuring total immunoglobulin A and tissue transglutaminase IgA antibodies and confirming positive results by endomysial an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gut
سال: 2003
ISSN: 0017-5749
DOI: 10.1136/gut.52.2.199